The Effects Of Sildenafil On Human Sperm Function In Healthy Volunteers


You must also ask your pharmacist any questions that you might have ahead of starting your dosage. Certain lifestyle and psychological factors, such as smoking, drinking, and stress, can have impact on erectile dysfunction. Along with its needed effects, Cobra 120 mg may cause some unwanted effects. cobra vega extra strong 120 mg

The Vega cobra 120 mg medication contains Sildenafil citrate 120 mg, which acts as the phosphodiesterase type- 5 inhibitors. This inhibits the degradation of chemical, cGMP, which is being produced in the tissues of the male organ during sensual stimulation. This facilitates the relaxation of muscles and acceleration in the flow of blood towards the male organ, thereby causing its erection. Morales A, Gingell C, Collins M, Wicker PA, Osterloh IH. Clinical safety of oral sildenafil citrate (Viagra™) in the treatment of erectile dysfunction. Mean semen concentrations of the metabolite were approximately 5% and 15% of the mean plasma concentrations at 1.5 h and 4 h, respectively.

In the structure of all acute diseases and injuries of cobra vega extra strong 120 mg and the scrotum in children traumatic injuries was 7.2 % . In the structure of closed injuries of the scrotum were mostly soft tissue injuries not requiring surgical intervention. The subjects were asked not to ejaculate for a minimum of 3 days before each dose of study drug. They were not permitted to consume products containing caffeine, methylxanthines or alcohol and were asked to refrain from unaccustomed exercise in the 48 h before each dose of study drug and while at the study centre. The subjects also were required not to use prescription or over-the-counter drugs during the study and were not permitted to smoke at the study centre.

Sildenafil increases blood flow to the penis following sexual stimulation and does this by blocking the enzyme responsible for cGMP breakdown. CGMP is a substance that relaxes and widens blood vessels and smooth muscle cells. This process allows men to keep an erection hard enough for sex. A total of 17 healthy male volunteers were enrolled in this double-blind, placebo-controlled study to determine the pharmacokinetics of sildenafil and its pharmacodynamic effects on sperm function and ejaculate quality. Sperm motility parameters were subject to analysis of variance that ascribed variation in the data to subjects, periods, treatments, subject-by-period interaction and analysis time. Adjusted treatment means, differences and 95% confidence intervals were obtained for each treatment averaging over analysis time and for each analysis time averaging over treatments.

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For a comprehensive list of adverse effects, check the content of the tab Side Effects.

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